| South Africa |
| 21 |
| England |
| 11 |
| 27 November 2010 | ||||||
| Twickenham, London | ||||||
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| Captain: Victor Matfield | Referee: George Clancy (Ireland) | |||||
| Coach: Peter de Villiers | Attendance: 80793 | |||||
| Position | Player | Province | Age | Prev Tests | Scoring |
| Loose-head Prop | Tendai Mtawarira | Sharks | 25 | 25 | |
| Hooker | Bismarck du Plessis | Sharks | 26 | 35 | |
| Tight-head Prop | Jannie du Plessis | Sharks | 28 | 23 | |
| Lock | Bakkies Botha | Blue Bulls | 31 | 71 | |
| Lock (C) | Victor Matfield | Blue Bulls | 33 | 104 | |
| Flank | Deon Stegmann | Blue Bulls | 24 | 3 | |
| Flank | Juan Smith | Cheetahs | 29 | 68 | |
| Eighthman | Pierre Spies | Blue Bulls | 25 | 39 | |
| Scrumhalf | Ruan Pienaar | Ulster | 26 | 46 | |
| Flyhalf | Morné Steyn | Blue Bulls | 26 | 24 | 1 conversion, 3 penalties |
| Left Wing | Lwazi Mvovo | Sharks | 24 | 1 | 1 try |
| Inside Centre | Jean de Villiers | WP | 29 | 66 | |
| Outside Centre | Francois Steyn | Racing | 23 | 41 | |
| Right Wing | Gio Aplon | WP | 28 | 12 | |
| Full Back | Zane Kirchner | Blue Bulls | 26 | 13 | |
| Reserve | Adrian Jacobs | Sharks | 30 | 31 | |
| Reserve | Willem Alberts | Sharks | 26 | 2 | 1 try |
| Reserve | CJ van der Linde | Cheetahs | 30 | 68 | |
| Reserve | Francois Hougaard | Blue Bulls | 22 | 7 | |
| Reserve | Flip van der Merwe | Blue Bulls | 25 | 9 | |
| Reserve | Adriaan Strauss | Cheetahs | 25 | 8 | |
| Reserve | Pat Lambie | Sharks | 20 | 3 |
| England: 1 try, 2 penalties |